Making choices

由 M Falk 著作 · 2018 · 被引用 36 次 — Collapsed replication forks thus represent the dominant type of damage in cryopreserved cells (DMSO or trehalose + DMSO), in which other effects ...

由 CM Kondratick 著作 · 2021 · 被引用 39 次 — Prolonged stalling of replication in cells leads to fork collapse, which involves disassembly of the replisome, fork reversal and/or breakage generating DNA ...

由 D Cortez 著作 · 2015 · 被引用 257 次 — Robust mechanisms ensure that stalled forks remain stable and capable of either resuming DNA synthesis or being rescued by converging forks.

由 JL Alexander 著作 · 2016 · 被引用 107 次 — Obstructions to replication fork progression cause fork stalling and increase the likelihood of fork collapse and breakage. Although stalled forks can resume ...

However, prolonged RF stalling leads to DNA damage; alternatively, the fork may collapse if Rad53 (Cds1 in fission yeast, or Chk1 in metazoa) is absent, and ...